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Article

Association between APOE ε2 and Aβ burden in patients with Alzheimer- and vascular-type cognitive impairment.

Neurology - 27 Oct 2020

Lee Jin San, Lee Hyejoo, Park Seongbeom, Choe Yeongsim, Park Yu Hyun, Cheon Bo Kyoung, Hahn Alice, Ossenkoppele Rik, Kim Hee Jin, Kim Seonwoo, Yoo Heejin, Jang Hyemin, Cho Soo Hyun, Kim Seung Joo, Kim Jun Pyo, Jung Young Hee, Park Key-Chung, DeCarli Charles, Weiner Michael W, Na Duk L, Seo Sang Won

Abstract excerpt

OBJECTIVE: To investigate the association between APOE genotype and β-amyloid (Aβ) burden, as measured by PET in patients with subcortical vascular cognitive impairment (SVCI) and those with Alzheimer disease-related cognitive impairment (ADCI). METHODS: This was a cross-sectional study of 310 patients with SVCI and 999 with ADCI. To evaluate the effects of APOE genotype or diagnostic group on Aβ positivity, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32928967
DOI: 10.1212/WNL.0000000000010811
PMCID: PMC7682916

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