Effects of APOE ε4 on brain amyloid, lacunar infarcts, and white matter lesions: a study among patients with subcortical vascular cognitive impairment.

doi:10.1016/j.neurobiolaging.2013.05.009

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Article

Effects of APOE ε4 on brain amyloid, lacunar infarcts, and white matter lesions: a study among patients with subcortical vascular cognitive impairment.

Neurobiology of aging - 1 Nov 2013

Kim Hee Jin, Ye Byoung Seok, Yoon Cindy W, Cho Hanna, Noh Young, Kim Geon Ha, Choi Yae Seul, Kim Jung-Hyun, Jeon Seun, Lee Jong Min, Kim Jae Seung, Choe Yearn Seong, Lee Kyung Han, Kim Sung Tae, Kim Changsoo, Kang Dae Ryong, Ki Chang-Seok, Lee Jae Hong, Werring David J, Weiner Michael W, Na Duk L, Seo Sang Won

Abstract excerpt

The relationship between the apolipoprotein E ε4 allele (APOE4) and factors associated with vascular cognitive impairment (VCI) is unclear. We aimed to examine the effects of APOE4 on brain amyloid beta using Pittsburg compound B (PiB) and subcortical cerebrovascular disease, as assessed by lacunes and white matter hyperintensities (WMH) in subcortical VCI (SVCI) patients. We recruited 230 subjects with normal...

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PMID: 23769398
DOI: 10.1016/j.neurobiolaging.2013.05.009

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APOE

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