Article
Mutational spectrum of hepatitis C virus in patients with chronic hepatitis C determined by single molecule real-time sequencing.
Scientific reports - 30 Apr 2022
Nakamura Fumiyasu, Takeda Haruhiko, Ueda Yoshihide, Takai Atsushi, Takahashi Ken, Eso Yuji, Arasawa Soichi, Iguchi Eriko, Shimizu Takahiro, Mishima Masako, Kumagai Ken, Yamashita Taiki, Uemoto Shinji, Kato Nobuyuki, Marusawa Hiroyuki, Sekine Akihiro, Seno Hiroshi
Abstract excerpt
The emergence of hepatitis C virus (HCV) with resistance-associated substitution (RAS), produced by mutations in the HCV genome, is a major problem in direct acting antivirals (DAA) treatment. This study aimed to clarify the mutational spectrum in HCV-RNA and the substitution pattern for the emergence of RASs in patients with chronic HCV infection. HCV-RNA from two HCV replicon cell lines and the serum HCV-RNA of...
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