Article
Identification of drug resistance and immune-driven variations in hepatitis C virus (HCV) NS3/4A, NS5A and NS5B regions reveals a new approach toward personalized medicine.
Antiviral research - 1 Jan 2017
Ikram Aqsa, Obaid Ayesha, Awan Faryal Mehwish, Hanif Rumeza, Naz Anam, Paracha Rehan Zafar, Ali Amjad, Janjua Hussnain Ahmed
Abstract excerpt
Cellular immune responses (T cell responses) during hepatitis C virus (HCV) infection are significant factors for determining the outcome of infection. HCV adapts to host immune responses by inducing mutations in its genome at specific sites that are important for HLA processing/presentation. Moreover, HCV also adapts to resist potential drugs that are used to restrict its replication, such as direct-acting...
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