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Article

Polymorphisms in matricellular SPP1 and SPARC contribute to susceptibility to papillary thyroid cancer.

Genomics - 1 Nov 2020

Su Xuan, Xu Bo-Heng, Zhou Da-Lei, Ye Zu-Lu, He Hui-Chan, Yang Xin-Hua, Zhang Xiao, Liu Qing, Ma Jiang-Jun, Shao Qiong, Yang An-Kui, He Cai-Yun

Abstract excerpt

There is a compelling need to identify novel genetic variants for papillary thyroid cancer (PTC) susceptibility. The Cancer Genome Atlas (TCGA) data showed associations between SPP1 and SPARC mRNA overexpression and aggressive behaviors of PTC, which prompted us to assess potential associations between genetic variants in these genes and PTC risk. Three highly linked SPARC loci (rs1054204, rs3210714, and rs3549)...

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Identifiers

PMID: 32919020
DOI: 10.1016/j.ygeno.2020.09.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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