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Integrative transcriptomics and single-cell transcriptomics analyses reveal potential biomarkers and mechanisms of action in papillary thyroid carcinoma

30 May 2025

Abstract excerpt

Objective: Papillary thyroid carcinoma (PTC) has a high recurrence rate and lacks reliable diagnostic biomarkers. This study aims to identify robust transcriptomic biomarkers for PTC diagnosis through integrative bioinformatics approaches and elucidate the cellular mechanisms underlying PTC pathogenesis at single-cell resolution. Methods: Based on the Gene Expression Omnibus (GEO) database, we downloaded...

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PMID: 40520228
DOI: 10.3389/fgene.2025.1536198

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