Article
A genome-wide association study yields five novel thyroid cancer risk loci.
Nature communications - 14 Feb 2017
Gudmundsson Julius, Thorleifsson Gudmar, Sigurdsson Jon K, Stefansdottir Lilja, Jonasson Jon G, Gudjonsson Sigurjon A, Gudbjartsson Daniel F, Masson Gisli, Johannsdottir Hrefna, Halldorsson Gisli H, Stacey Simon N, Helgason Hannes, Sulem Patrick, Senter Leigha, He Huiling, Liyanarachchi Sandya, Ringel Matthew D, Aguillo Esperanza, Panadero Angeles, Prats Enrique, Garcia-Castaño Almudena, De Juan Ana, Rivera Fernando, Xu Li, Kiemeney Lambertus A, Eyjolfsson Gudmundur I, Sigurdardottir Olof, Olafsson Isleifur, Kristvinsson Hoskuldur, Netea-Maier Romana T, Jonsson Thorvaldur, Mayordomo Jose I, Plantinga Theo S, Hjartarson Hannes, Hrafnkelsson Jon, Sturgis Erich M, Thorsteinsdottir Unnur, Rafnar Thorunn, de la Chapelle Albert, Stefansson Kari
Abstract excerpt
The great majority of thyroid cancers are of the non-medullary type. Here we report findings from a genome-wide association study of non-medullary thyroid cancer, including in total 3,001 patients and 287,550 controls from five study groups of European descent. Our results yield five novel loci (all with Pcombined<3 × 10-8): 1q42.2 (rs12129938 in PCNXL2), 3q26.2 (rs6793295 a missense mutation in LRCC34 near...
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