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Article

SPP1 rs4754 and its epistatic interactions with SPARC polymorphisms in gastric cancer susceptibility.

Gene - 15 Jan 2018

Chen Le-Zong, He Cai-Yun, Su Xuan, Peng Jun-Ling, Chen Dong-Liang, Ye Zulu, Yang Dong-Dong, Wang Zi-Xian, Wang Feng, Shao Jian-Yong, Xu Rui-Hua

Abstract excerpt

The matricellular glycoprotein products of the SPP1 and SPARC genes play critical roles in many aggressive tumor phenotypes including gastric cancer. We sought to test whether the polymorphisms of these two genes, individually or jointly, influence gastric cancer susceptibility. Nine potentially functional, tagging single nucleotide polymorphisms (tagSNPs) of SPP1 and SPARC were selected and detected using the...

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Source

Identifiers

PMID: 28962925
DOI: 10.1016/j.gene.2017.09.053

Genes

SPP1
SPARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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