Article
MEAF6 is essential for cell proliferation and plays a role in the assembly of KAT7 complexes.
Experimental cell research - 1 Nov 2020
Matsuura Kumi, Tani Naoki, Usuki Shingo, Torikai-Nishikawa Satomi, Okano Masaki, Niwa Hitoshi
Abstract excerpt
Myst family genes encode lysine acetyltransferases that mainly mediate histone acetylation to control transcription, DNA replication and DNA damage response. They form tetrameric complexes with PHD-finger proteins (Brpfs or Jades) and small non-catalytic subunits Ing4/5 and Meaf6. Although all the components of the complex are well-conserved from yeast to mammals, the function of Meaf6 and its homologs has not...
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