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Article

The roles of the acetyltransferase domains of the chromatin regulators KAT6A and KAT6B in vivo.

Development (Cambridge, England) - 15 Jun 2026

Thomas Tim, Malelang Shezlie, Yang Yuqing, Bergamasco Maria I, Kueh Andrew J, Garnham Alexandra L, Ranathunga Nishika, Smyth Gordon K, Voss Anne K

Abstract excerpt

KAT6A (MOZ) and KAT6B (QKF/MORF) are related histone lysine acetyltransferases (KATs) that have a high degree of functional redundancy during development. In the absence of KAT6A, embryos undergo an anterior homeotic transformation of the axial skeleton, develop an interrupted aortic arch, have ventricular septal defects and fail to form definitive hematopoietic stem cells. KAT6B has roles in brain, skeletal and...

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Topics

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Share to Acetylation
Share to Chromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Septal Defects, Ventricular

Share to Hematopoietic Stem Cells

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Source

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Identifiers

PMID: 42227022
DOI: 10.1242/dev.205559
PMCID: PMC13327545

Genes

KAT6A
KAT6B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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The roles of the acetyltransferase domains of the chromatin regulators KAT6A and KAT6B in vivo.PMID 42227022Read ↗

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