Article
Single-cell mass cytometry of microglia in major depressive disorder reveals a non-inflammatory phenotype with increased homeostatic marker expression.
Translational psychiatry - 11 Sept 2020
Böttcher Chotima, Fernández-Zapata Camila, Snijders Gijsje J L, Schlickeiser Stephan, Sneeboer Marjolein A M, Kunkel Desiree, De Witte Lot D, Priller Josef
Abstract excerpt
Stress-induced disturbances of brain homeostasis and neuroinflammation have been implicated in the pathophysiology of mood disorders. In major depressive disorder (MDD), elevated levels of proinflammatory cytokines and chemokines can be found in peripheral blood, but very little is known about the changes that occur directly in the brain. Microglia are the primary immune effector cells of the central nervous...
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