Article
A comprehensive analysis of adiponectin QTLs using SNP association, SNP cis-effects on peripheral blood gene expression and gene expression correlation identified novel metabolic syndrome (MetS) genes with potential role in carcinogenesis and systemic inflammation.
BMC medical genomics - 29 Apr 2013
Zhang Yi, Kent Jack W, Olivier Michael, Ali Omar, Cerjak Diana, Broeckel Ulrich, Abdou Reham M, Dyer Thomas D, Comuzzie Anthony, Curran Joanne E, Carless Melanie A, Rainwater David L, Göring Harald H H, Blangero John, Kissebah Ahmed H
Abstract excerpt
BACKGROUND: Metabolic syndrome (MetS) is an aberration associated with increased risk for cancer and inflammation. Adiponectin, an adipocyte-produced abundant protein hormone, has countering effect on the diabetogenic and atherogenic components of MetS. Plasma levels of adiponectin are negatively correlated with onset of cancer and cancer patient mortality. We previously performed microsatellite linkage analyses...
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