Article
Striatal dopamine gene network moderates the effect of early adversity on the risk for adult psychiatric and cardiometabolic comorbidity.
Scientific reports - 9 Nov 2024
Barth Barbara, Arcego Danusa Mar, de Mendonça Filho Euclides José, de Lima Randriely Merscher Sobreira, Parent Carine, Dalmaz Carla, Portella André Krumel, Pokhvisneva Irina, Meaney Michael J, Silveira Patricia Pelufo
Abstract excerpt
Cardiometabolic and psychiatric disorders often co-exist and share common early life risk factors, such as low birth weight. However, the biological pathways linking early adversity to adult cardiometabolic/psychiatric comorbidity remain unknown. Dopamine (DA) neurotransmission in the striatum is sensitive to early adversity and influences the development of both cardiometabolic and psychiatric diseases. Here we...
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