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Article

Right Posterior Insula and Putamen Volume Mediate the Effect of Oxytocin Receptor Polygenic Risk for Autism Spectrum Disorders on Reward Dependence in Healthy Adults.

Cerebral cortex (New York, N.Y. : 1991) - 5 Jan 2021

Wang Junping, Zhang Peng, Li Wei, Wen Qin, Liu Feng, Xu Jiayuan, Xu Qiang, Zhu Dan, Ye Zhaoxiang, Yu Chunshui

Abstract excerpt

Much evidence indicates the influence of the oxytocin receptor (OXTR) gene on autism spectrum disorders (ASDs), a set of disorders characterized by a range of deficits in prosocial behaviors, which are closely related to the personality trait of reward dependence (RD). However, we do not know the effect of the OXTR polygenic risk score for ASDs (OXTR-PRSASDs) on RD and its underlying neuroanatomical substrate....

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Identifiers

PMID: 32710107
DOI: 10.1093/cercor/bhaa198

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