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Article

Clinicogenomic Landscape of Histologic Subtypes in Ovarian Cancer: Real-World Evidence From a Japanese Nationwide Cohort.

JCO precision oncology - 1 Jun 2026

Tamaki Ryuji, Kogai Hiroyuki, Sagane Koji, Aoshima Ken, Li Shuyu D

Abstract excerpt

PURPOSE: The frequency of histologic subtypes in epithelial ovarian cancer (EOC) varies by geographic region. In Western countries, high-grade serous ovarian cancer (HGSOC) is the most common and well characterized, whereas non-HGSOC subtypes, particularly clear cell ovarian cancer (CCOV), are more prevalent in Asia. However, their clinicogenomic features remain poorly defined. PATIENTS AND METHODS: This...

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Aged
Carcinoma, Ovarian Epithelial
Cohort Studies
ARID1A gene
KEAP1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovarian Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 42284540
DOI: 10.1200/PO-25-01149
PMCID: PMC13268116

Genes

CDKN2A
CDKN2B
PIK3CA
TP53
ARID1A
BRCA1
BRCA2
CAT
KEAP1
KRAS
NFE2L2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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