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Article

Human model of IRX5 mutations reveals key role for this transcription factor in ventricular conduction

28 Aug 2020

Abstract excerpt

AIMS: Several inherited arrhythmic diseases have been linked to single gene mutations in cardiac ion channels and interacting proteins. However, the mechanisms underlying most arrhythmias, are thought to involve altered regulation of the expression of multiple effectors. In this study, we aimed to examine the role of a transcription factor (TF) belonging to the Iroquois homeobox family, IRX5, in cardiac...

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PMID: 32898233
DOI: 10.1093/cvr/cvaa259

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