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Article

Genetic defects in a His-Purkinje system transcription factor,<i>IRX3</i>, cause lethal cardiac arrhythmias

1 Oct 2015

Abstract excerpt

AIM: Ventricular fibrillation (VF), the main cause of sudden cardiac death (SCD), occurs most frequently in the acute phase of myocardial infarction: a certain fraction of VF, however, develops in an apparently healthy heart, referred as idiopathic VF. The contribution of perturbation in the fast conduction system in the ventricle, the His-Purkinje system, for idiopathic VF has been implicated, but the underlying...

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PMID: 26429810
DOI: 10.1093/eurheartj/ehv449

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