Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional regulation of the sodium channel gene (SCN5A) by GATA4 in human heart.

Journal of molecular and cellular cardiology - 1 Jan 2017

Tarradas Anna, Pinsach-Abuin Mel Lina, Mackintosh Carlos, Llorà-Batlle Oriol, Pérez-Serra Alexandra, Batlle Montserrat, Pérez-Villa Félix, Zimmer Thomas, Garcia-Bassets Ivan, Brugada Ramon, Beltran-Alvarez Pedro, Pagans Sara

Abstract excerpt

Aberrant expression of the sodium channel gene (SCN5A) has been proposed to disrupt cardiac action potential and cause human cardiac arrhythmias, but the mechanisms of SCN5A gene regulation and dysregulation still remain largely unexplored. To gain insight into the transcriptional regulatory networks of SCN5A, we surveyed the promoter and first intronic regions of the SCN5A gene, predicting the presence of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to GATA4 Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Myocardium

Share to NAV1.5 Voltage-Gated Sodium Channel

Share to RNA, Small Interfering

Share to Transcription, Genetic

Source

Identifiers

PMID: 27894866
DOI: 10.1016/j.yjmcc.2016.10.013

Genes

GATA4
GATA5
GATA6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional regulation of the sodium channel gene (SCN5A) by GATA4 in human heart.PMID 27894866Read ↗

Deciphering transcriptional networks during human cardiac developmentSemantic proximity Read ↗

Potential roles of GATA binding protein 5 in cardiovascular diseases.Semantic proximity Read ↗

Elucidating the mechanisms of transcription regulation during heart development by next-generation sequencing.Semantic proximity Read ↗

Cloning and initial characterization of the human cardiac sodium channel (SCN5A) promoterSemantic proximity Read ↗

Transcription Factor GATA4 Regulates Cell Type–Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell–Derived Cardiac ProgenitorsSemantic proximity Read ↗

A common genetic variant within SCN10A modulates cardiac SCN5A expression.Semantic proximity Read ↗

GATA5 loss-of-function mutation in familial dilated cardiomyopathy.Semantic proximity Read ↗

Cardiac Cell Type-Specific Gene Regulatory Programs and Disease Risk AssociationSemantic proximity Read ↗

Human atlas of cardiac promoters and enhancers reveals important role of regulatory elements in heritable diseasesSemantic proximity Read ↗

From embryogenesis to adulthood: Critical role for GATA factors in heart development and functionSemantic proximity Read ↗

Human library of cardiac promoters and enhancersSemantic proximity Read ↗

Novel and functional DNA sequence variants within the GATA5 gene promoter in ventricular septal defects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.