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Article

SAIGEgds-an efficient statistical tool for large-scale PheWAS with mixed models.

Bioinformatics (Oxford, England) - 5 May 2021

Zheng Xiuwen, Davis J Wade

Abstract excerpt

SUMMARY: Phenome-wide association studies (PheWASs) are known to be a powerful tool in discovery and replication of genetic association studies. To reduce the computational burden of PheWAS in the large cohorts, such as the UK Biobank, the SAIGE method has been proposed to control for case-control imbalance and sample relatedness in a tractable manner. However, SAIGE is still computationally intensive when...

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PMID: 32898220
DOI: 10.1093/bioinformatics/btaa731

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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