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Article

PheWAS analysis on large-scale biobank data with PheTK.

Bioinformatics (Oxford, England) - 26 Dec 2024

Tran Tam C, Schlueter David J, Zeng Chenjie, Mo Huan, Carroll Robert J, Denny Joshua C

Abstract excerpt

SUMMARY: With the rapid growth of genetic data linked to electronic health record (EHR) data in huge cohorts, large-scale phenome-wide association study (PheWAS) have become powerful discovery tools in biomedical research. PheWAS is an analysis method to study phenotype associations utilizing longitudinal EHR data. Previous PheWAS packages were developed mostly with smaller datasets and with earlier PheWAS...

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PMID: 39657951
DOI: 10.1093/bioinformatics/btae719

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