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Article

A Fast and Accurate Method for Genome-wide Scale Phenome-wide G × E Analysis and Its Application to UK Biobank.

American journal of human genetics - 5 Dec 2019

Bi Wenjian, Zhao Zhangchen, Dey Rounak, Fritsche Lars G, Mukherjee Bhramar, Lee Seunggeun

Abstract excerpt

The etiology of most complex diseases involves genetic variants, environmental factors, and gene-environment interaction (G × E) effects. Compared with marginal genetic association studies, G × E analysis requires more samples and detailed measure of environmental exposures, and this limits the possible discoveries. Large-scale population-based biobanks with detailed phenotypic and environmental information, such...

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Identifiers

PMID: 31735295
DOI: 10.1016/j.ajhg.2019.10.008
PMCID: PMC6904814

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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