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Article

Structural properties of target binding by profilaggrin A and B domains and other S100 fused-type calcium-binding proteins.

Journal of dermatological science - 1 Oct 2020

Hinbest Alexander J, Kim Sa Rang, Eldirany Sherif A, Lomakin Ivan B, Watson Joseph, Ho Minh, Bunick Christopher G

Abstract excerpt

BACKGROUND: Profilaggrin belongs to the S100 fused-type protein family expressed in keratinocytes and is important for skin barrier integrity. Its N-terminus contains an S100 ("A") domain and a unique "B" domain with a nuclear localization sequence. OBJECTIVE: To determine whether profilaggrin B domain cooperates with the S100 domain to bind macromolecules. To characterize the biochemical and structural...

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Identifiers

PMID: 32893105
DOI: 10.1016/j.jdermsci.2020.08.009
PMCID: PMC7752840

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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