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Article

Pathogenic role of S100 proteins in psoriasis

6 Jun 2023

Abstract excerpt

Psoriasis is a chronic inflammatory skin disease. The histopathological features of psoriasis include excessive proliferation of keratinocytes and infiltration of immune cells. The S100 proteins are a group of EF-hand Ca 2+ -binding proteins, including S100A2, -A7, -A8/A9, -A12, -A15, which expression levels are markedly upregulated in psoriatic skin. These proteins exert numerous functions such as serving as...

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PMID: 37346040
DOI: 10.3389/fimmu.2023.1191645

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