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Article

Modifier genes in Mendelian disorders: the example of hemoglobin disorders.

Annals of the New York Academy of Sciences - 1 Dec 2010

Sankaran Vijay G, Lettre Guillaume, Orkin Stuart H, Hirschhorn Joel N

Abstract excerpt

The disorders of hemoglobin, including sickle cell disease (SCD) and β-thalassemia, are the most common "Mendelian" genetic diseases in the world. Numerous studies have demonstrated the complexity in making genotype-phenotype correlations in both SCD and β-thalassemia. Indeed, patients with exact...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21039591
DOI: 10.1111/j.1749-6632.2010.05821.x

Genes

SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21039591-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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