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Limitations of Hb F as a phenotypic modifier in sickle cell disease: study of Kuwaiti Arab patients.

Hemoglobin - 1 Jan 2011

Adekile Adekunle D

Abstract excerpt

Sickle cell disease is characterized by phenotypic heterogeneity and many genetic modifiers have been identified with elevated Hb F being the most recognized ameliorating factor. Kuwaiti sickle cell disease patients carry the India/Arab chromosomal haplotype, which is associated with elevated Hb F (on average ~22%) on account of the Xmn1 site in the (G)γ-globin gene promoter. Most patients had either Hb SS or Hb...

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PMID: 21999156
DOI: 10.3109/03630269.2011.617230

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