Article
Assessment of genetic susceptibility to multiple primary cancers through whole-exome sequencing in two large multi-ancestry studies.
BMC medicine - 6 Oct 2022
Cavazos Taylor B, Kachuri Linda, Graff Rebecca E, Nierenberg Jovia L, Thai Khanh K, Alexeeff Stacey, Van Den Eeden Stephen, Corley Douglas A, Kushi Lawrence H, Hoffmann Thomas J, Ziv Elad, Habel Laurel A, Jorgenson Eric, Sakoda Lori C, Witte John S
Abstract excerpt
BACKGROUND: Up to one of every six individuals diagnosed with one cancer will be diagnosed with a second primary cancer in their lifetime. Genetic factors contributing to the development of multiple primary cancers, beyond known cancer syndromes, have been underexplored. METHODS: To characterize genetic susceptibility to multiple cancers, we conducted a pan-cancer, whole-exome sequencing study of individuals...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.