Article
The Mla pathway in Acinetobacter baumannii has no demonstrable role in anterograde lipid transport.
eLife - 3 Sept 2020
Powers Matthew J, Simpson Brent W, Trent M Stephen
Abstract excerpt
The asymmetric outer membrane (OM) of Gram-negative bacteria functions as a selective permeability barrier to the environment. Perturbations to OM lipid asymmetry sensitize the cell to antibiotics. As such, mechanisms involved in lipid asymmetry are fundamental to our understanding of OM lipid homeostasis. One such mechanism, the Maintenance of lipid asymmetry (Mla) pathway has been proposed to extract...
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