Article
The role of the essential GTPase ObgE in regulating lipopolysaccharide synthesis in Escherichia coli.
Nature communications - 8 Nov 2024
Dewachter Liselot, Deckers Babette, Mares-Mejía Israel, Louwagie Elen, Vercauteren Silke, Matthay Paul, Brückner Simon, Möller Anna-Maria, Narberhaus Franz, Vonesch Sibylle C, Versées Wim, Michiels Jan
Abstract excerpt
During growth, cells need to synthesize and expand their envelope, a process that requires careful regulation. Here, we show that the GTPase ObgE of E. coli contributes to the regulation of lipopolysaccharide (LPS) synthesis, an essential component of the Gram-negative outer membrane. Using a dominant-negative mutant (named 'ObgE*'), we show a direct interaction between ObgE and LpxA, which catalyzes the first...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.