Article
Structural basis for maintenance of bacterial outer membrane lipid asymmetry.
Nature microbiology - 1 Dec 2017
Abellón-Ruiz Javier, Kaptan Shreyas S, Baslé Arnaud, Claudi Beatrice, Bumann Dirk, Kleinekathöfer Ulrich, van den Berg Bert
Abstract excerpt
The Gram-negative bacterial outer membrane (OM) is a unique bilayer that forms an efficient permeation barrier to protect the cell from noxious compounds 1,2 . The defining characteristic of the OM is lipid asymmetry, with phospholipids comprising the inner leaflet and lipopolysaccharides comprising the outer leaflet 1-3 . This asymmetry is maintained by the Mla pathway, a six-component system that is widespread...
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