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Lipoarabinomannan mediates localized cell wall integrity during division in mycobacteria

11 Mar 2024

Abstract excerpt

The growth and division of mycobacteria, which include clinically relevant pathogens, deviate from that of canonical bacterial models. Despite their Gram-positive ancestry, mycobacteria synthesize and elongate a diderm envelope asymmetrically from the poles, with the old pole elongating more robustly than the new pole. The phosphatidylinositol-anchored lipoglycans lipomannan (LM) and lipoarabinomannan (LAM) are...

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PMID: 38467648
DOI: 10.1038/s41467-024-46565-5

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