Article
Disruption of lipid homeostasis in the Gram-negative cell envelope activates a novel cell death pathway.
Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 2016
Sutterlin Holly A, Shi Handuo, May Kerrie L, Miguel Amanda, Khare Somya, Huang Kerwyn Casey, Silhavy Thomas J
Abstract excerpt
Gram-negative bacteria balance synthesis of the outer membrane (OM), cell wall, and cytoplasmic contents during growth via unknown mechanisms. Here, we show that a dominant mutation (designated mlaA*, maintenance of lipid asymmetry) that alters MlaA, a lipoprotein that removes phospholipids from the outer leaflet of the OM of Escherichia coli, increases OM permeability, lipopolysaccharide levels, drug...
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