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Identification of Recurrent Variants in BRCA1 and BRCA2 across Multiple Cancers in the Chinese Population.

BioMed research international - 1 Jan 2020

Jiang Yue, Tian Ting, Yu Chengxiao, Zhou Wen, Yang Junzhe, Wang Yifeng, Wen Yang, Chen Jiaping, Dai Juncheng, Jin Guangfu, Ma Hongxia, Shen Hongbing, Hu Zhibin

Abstract excerpt

BRCA1 and BRCA2 as important DNA repair genes have been thoroughly investigated in abundant studies. The potential relationships of BRCA1/2 pathogenic variants between multicancers have been verified in Caucasians but few in Chinese. In this study, we performed a two-stage study to screen BRCA1/2 pathogenic variants or variants of uncertain significance (VUS) with 7580 cancer cases and 4874 cancer-free controls,...

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Identifiers

PMID: 32879886
DOI: 10.1155/2020/6739823
PMCID: PMC7448236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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