Identification of recurrent BRCA1 mutation and its clinical relevance in Chinese Triple-negative breast cancer cohort.

doi:10.1002/cam4.1004

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Identification of recurrent BRCA1 mutation and its clinical relevance in Chinese Triple-negative breast cancer cohort.

Cancer medicine - 1 Mar 2017

Liu Xiaoran, Li Huiping, Shao Bin, Wu Jianmin, Kong Weiyao, Song Guohong, Jiang Hanfang, Wang Jing, Wan Fengling

Abstract excerpt

Triple-negative breast cancer (TNBC) accounts for 15-20% of all newly diagnosed breast cancers, and is enriched for germline mutation of BRCA. In Asian patients diagnosed with breast cancer, 268 deleterious mutations of BRCA1 and 242 of BRCA2 have been identified so far, including a reported BRCA1 frameshift mutation (rs80350973), apparently found only in Asian people, with a low prevalence of 0.3-1.7% in...

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PMID: 28135048
DOI: 10.1002/cam4.1004
PMCID: PMC5345662

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BRCA1
BRCA2

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