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Prevalence and characterization of BRCA1 and BRCA2 germline mutations in Chinese women with familial breast cancer.

Breast cancer research and treatment - 1 Apr 2012

Zhang Juan, Pei Renguang, Pang Zhiyuan, Ouyang Tao, Li Jinfeng, Wang Tianfeng, Fan Zhaoqing, Fan Tie, Lin Benyao, Xie Yuntao

Abstract excerpt

Although there are some studies to investigate germline mutations in BRCA1/2 genes in Chinese women with familial breast cancer, many of them suffer relatively small sample size. In this study, we screened germline mutations in BRCA1/2 genes in a cohort of 409 Chinese women with familial breast cancer from north China by using a PCR-sequencing assay. A total of 43 deleterious mutations in BRCA1/2 genes were...

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BRCA1 Protein
BRCA2 Protein
Chi-Square Distribution
Germ-Line Mutation
Heredity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptor, ErbB-2

Receptors, Estrogen

Receptors, Progesterone

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PMID: 21614564
DOI: 10.1007/s10549-011-1596-x

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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