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Article

Alpha synuclein aggresomes inhibit ciliogenesis and multiple functions of the centrosome

1 Jan 2020

Abstract excerpt

Protein aggregates are the pathogenic hallmarks of many different neurodegenerative diseases and include the accumulation of α-synuclein, the main component of Lewy bodies found in Parkinson's disease. Aggresomes are closely-related, cellular accumulations of misfolded proteins. They develop in a juxtanuclear position, adjacent to the centrosome, the microtubule organizing centre of the cell, and share some...

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PMID: 32878882
DOI: 10.1242/bio.054338

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Alpha synuclein aggresomes inhibit ciliogenesis and multiple functions of the centrosomePMID 32878882Read ↗

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