Article
Integrating genotypes and phenotypes improves long-term forecasts of seasonal influenza A/H3N2 evolution.
eLife - 2 Sept 2020
Huddleston John, Barnes John R, Rowe Thomas, Xu Xiyan, Kondor Rebecca, Wentworth David E, Whittaker Lynne, Ermetal Burcu, Daniels Rodney Stuart, McCauley John W, Fujisaki Seiichiro, Nakamura Kazuya, Kishida Noriko, Watanabe Shinji, Hasegawa Hideki, Barr Ian, Subbarao Kanta, Barrat-Charlaix Pierre, Neher Richard A, Bedford Trevor
Abstract excerpt
Seasonal influenza virus A/H3N2 is a major cause of death globally. Vaccination remains the most effective preventative. Rapid mutation of hemagglutinin allows viruses to escape adaptive immunity. This antigenic drift necessitates regular vaccine updates. Effective vaccine strains need to represent H3N2 populations circulating one year after strain selection. Experts select strains based on experimental...
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