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Article

Machine Learning Prediction and Experimental Validation of Antigenic Drift in H3 Influenza A Viruses in Swine.

mSphere - 17 Mar 2021

Zeller Michael A, Gauger Phillip C, Arendsee Zebulun W, Souza Carine K, Vincent Amy L, Anderson Tavis K

Abstract excerpt

The antigenic diversity of influenza A viruses (IAV) circulating in swine challenges the development of effective vaccines, increasing zoonotic threat and pandemic potential. High-throughput sequencing technologies can quantify IAV genetic diversity, but there are no accurate approaches to adequately describe antigenic phenotypes. This study evaluated an ensemble of nonlinear regression models to estimate virus...

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Share to Antigenic Variation
Share to Hemagglutinin Glycoproteins, Influenza Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Influenza A Virus, H3N2 Subtype

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Share to Orthomyxoviridae Infections

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Source

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Identifiers

PMID: 33731472
DOI: 10.1128/mSphere.00920-20
PMCID: PMC8546707

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