Article
Genes with de novo mutations are shared by four neuropsychiatric disorders discovered from NPdenovo database.
Molecular psychiatry - 1 Feb 2016
Li Jinchen, Cai Tao, Jiang Yi, Chen Huiqian, He Xin, Chen Chao, Li Xianfeng, Shao Qianzhi, Ran Xia, Li Zhongshan, Xia Kun, Liu Chunyu, Sun Zhong Sheng, Wu Jinyu
Abstract excerpt
Currently, many studies on neuropsychiatric disorders have utilized massive trio-based whole-exome sequencing (WES) and whole-genome sequencing (WGS) to identify numerous de novo mutations (DNMs). Here, we retrieved 17,104 DNMs from 3555 trios across four neuropsychiatric disorders: autism spectrum disorder, epileptic encephalopathy, intellectual disability and schizophrenia, in addition to unaffected siblings...
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