Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumor-Resident Stromal Cells Promote Breast Cancer Invasion through Regulation of the Basal Phenotype.

Molecular cancer research : MCR - 1 Nov 2020

Hanley Christopher J, Henriet Elodie, Sirka Orit Katarina, Thomas Gareth J, Ewald Andrew J

Abstract excerpt

Collective invasion can be led by breast cancer cells expressing basal epithelial markers, typified by keratin-14 (KRT14). We analyzed gene expression data from The Cancer Genome Atlas and demonstrated a significant correlation between a KRT14+ invasion signature and a stromal-mediated extracellular matrix (ECM) organization module. We then developed a novel coculture model of tumor organoids with autologous...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Computational Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Invasiveness

Share to Phenotype

Share to Stromal Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 32868298
DOI: 10.1158/1541-7786.MCR-20-0334
PMCID: PMC7642004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumor-Resident Stromal Cells Promote Breast Cancer Invasion through Regulation of the Basal Phenotype.PMID 32868298Read ↗

Why the stroma matters in breast cancer: insights into breast cancer patient outcomes through the examination of stromal biomarkers.Semantic proximity Read ↗

Single-cell RNA reveals a tumorigenic microenvironment in the interface zone of human breast tumorsSemantic proximity Read ↗

Integrated multi-omics reveals cellular and molecular interactions governing the invasive niche of basal cell carcinomaSemantic proximity Read ↗

Molecular signatures suggest a major role for stromal cells in development of invasive breast cancer.Semantic proximity Read ↗

Spatiotemporal dynamics of tumor microenvironment remodelingSemantic proximity Read ↗

Cell non-autonomous interactions during non-immune stromal progression in the breast tumor microenvironmentSemantic proximity Read ↗

Single-cell transcriptome analysis reveals evolutionarily conserved features during the transition from normal breast stromal cells to cancer-associated fibroblastsSemantic proximity Read ↗

Large-scale Characterization of Orthotopic Cell Line–Derived Xenografts Identifies TGFβ Signaling as a Key Regulator of Breast Cancer Morphology and AggressivenessSemantic proximity Read ↗

Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reactionSemantic proximity Read ↗

Cancer-associated Fibroblast Spatial Heterogeneity and <i>EMILIN1</i> Expression in Cancer Stroma Modulate TGF-β Activity and CD8 <sup>+</sup> T-Cell Infiltration in Breast CancerSemantic proximity Read ↗

The Epithelial-to-Mesenchymal Transition in Breast Cancer: Focus on Basal-Like CarcinomasSemantic proximity Read ↗

Cancer-associated fibroblast spatial heterogeneity and EMILIN1 expression in the tumor microenvironment modulate TGF-β activity and CD8 + T-cell infiltration in breast cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.