Article
Molecular signatures suggest a major role for stromal cells in development of invasive breast cancer.
Breast cancer research and treatment - 1 Mar 2009
Casey Theresa, Bond Jeffrey, Tighe Scott, Hunter Timothy, Lintault Laura, Patel Osman, Eneman Jonathan, Crocker Abigail, White Jeffrey, Tessitore Joseph, Stanley Mary, Harlow Seth, Weaver Donald, Muss Hyman, Plaut Karen
Abstract excerpt
BACKGROUND: Breast cancer invasion and metastasis involves both epithelial and stromal changes. Our objective was to delineate the pivotal role stroma plays in invasion by comparing transcriptomes among stromal and epithelial cells in normal tissue and invasive breast cancer. METHODS: Total RNA was isolated from epithelial and stromal cells that were laser captured from normal breast tissue (n = 5) and invasive...
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