Large-scale Characterization of Orthotopic Cell Line–Derived Xenografts Identifies TGFβ Signaling as a Key Regulator of Breast Cancer Morphology and Aggressiveness

Abstract excerpt

Breast cancer is a heterogeneous disease with diverse morphologic and molecular subtypes. Preclinical models that recapitulate the heterogeneity of human breast cancer are needed to advance our fundamental understanding of what makes breast cancer an aggressive disease. To study mechanisms underlying breast cancer progression, we generated orthotopic cell line-derived xenograft (CDX) models from 20 different...