Article

L-type voltage-gated calcium channel agonists improve hearing loss and modify ribbon synapse morphology in the zebrafish model of Usher Syndrome Type 1

2019-12-16

Abstract excerpt

Usher Syndrome (USH) is the most common cause of human deaf/blindness. The zebrafish myo7aa -/- mutant, faithfully models USH1; homozygous zebrafish are deaf and exhibit circular swimming. We hypothesized that hair cell morphology would differ in myo7aa -/- mutants compared to wild type. We also tested the hypothesis that agonists of L-type voltage-gated calcium channels would alter ribbon synapse morphology a...

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Literature Corpus work: 6a70a908-1dfc-539e-84bf-f6cefe0fb5ad
DOI: 10.1101/2019.12.16.878231

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