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Article

L-type voltage-gated calcium channel agonists mitigate hearing loss and modify ribbon synapse morphology in the zebrafish model of Usher syndrome type 1.

Disease models & mechanisms - 27 Nov 2020

Koleilat Alaa, Dugdale Joseph A, Christenson Trace A, Bellah Jeffrey L, Lambert Aaron M, Masino Mark A, Ekker Stephen C, Schimmenti Lisa A

Abstract excerpt

The mariner (myo7aa-/- ) mutant is a zebrafish model for Usher syndrome type 1 (USH1). To further characterize hair cell synaptic elements in myo7aa-/- mutants, we focused on the ribbon synapse and evaluated ultrastructure, number and distribution of immunolabeled ribbons, and postsynaptic densities. By transmission electron microscopy, we determined that myo7aa-/- zebrafish have fewer glutamatergic vesicles...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33361086
DOI: 10.1242/dmm.043885
PMCID: PMC7710014

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