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Article

Loss of Stim2 in zebrafish induces glaucoma-like phenotype.

Scientific reports - 18 Oct 2024

Baranykova Sofiia, Gupta Rishikesh Kumar, Kajdasz Arkadiusz, Wasilewska Iga, Macias Matylda, Szybinska Aleksandra, Węgierski Tomasz, Nahia Karim Abu, Mondal Shamba S, Winata Cecilia L, Kuźnicki Jacek, Majewski Lukasz

Abstract excerpt

Calcium is involved in vision processes in the retina and implicated in various pathologies, including glaucoma. Rod cells rely on store-operated calcium entry (SOCE) to safeguard against the prolonged lowering of intracellular calcium ion concentrations. Zebrafish that lacked the endoplasmic reticulum Ca2+ sensor Stim2 (stim2 knockout [KO]) exhibited impaired vision and lower light perception-related gene...

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Identifiers

PMID: 39424970
DOI: 10.1038/s41598-024-74909-0
PMCID: PMC11489432

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