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Article

MDC1 functionally identified as an androgen receptor co-activator participates in suppression of prostate cancer

30 Apr 2015

Abstract excerpt

Mediator of DNA damage checkpoint protein 1 (MDC1) is essential for DNA damage response. However, the role of MDC1 in modulating gene transcription independently of DNA damage and the underlying mechanisms have not been fully defined. Androgen receptor (AR) is the central signaling pathway in prostate cancer (PCa) and its target genes are involved in both promotion and suppression of PCa. Here, we functionally...

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PMID: 25934801
DOI: 10.1093/nar/gkv394

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