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Article

Oligomerization of MDC1 protein is important for proper DNA damage response.

The Journal of biological chemistry - 12 Aug 2011

Luo Kuntian, Yuan Jian, Lou Zhenkun

Abstract excerpt

Mediator of DNA damage checkpoint 1 (MDC1) plays an important role in the DNA damage response (DDR). MDC1 functions as a mediator protein and binds multiple proteins involved in different aspects of the DDR. However, little is know about the organization of MDC1 complexes. Here we show that ataxia telangiectasia, mutated (ATM) phosphorylates MDC1 at Thr-98 following DNA damage, which promotes its oligomerization....

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Source

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Identifiers

PMID: 21705321
DOI: 10.1074/jbc.M111.258087
PMCID: PMC3151064

Genes

MDC1
ATM

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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