Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic Regulation of Fibroblast Activation and Proliferation in Cardiac Fibrosis.

Circulation - 18 Sept 2018

Park Shuin, Ranjbarvaziri Sara, Lay Fides D, Zhao Peng, Miller Mark J, Dhaliwal Jasmeet S, Huertas-Vazquez Adriana, Wu Xiuju, Qiao Rong, Soffer Justin M, Rau Christoph, Wang Yibin, Mikkola Hanna K A, Lusis Aldons J, Ardehali Reza

Abstract excerpt

BACKGROUND: Genetic diversity and the heterogeneous nature of cardiac fibroblasts (CFbs) have hindered characterization of the molecular mechanisms that regulate cardiac fibrosis. The Hybrid Mouse Diversity Panel offers a valuable tool to examine genetically diverse cardiac fibroblasts and their role in fibrosis. METHODS: Three strains of mice (C57BL/6J, C3H/HeJ, and KK/HlJ) were selected from the Hybrid Mouse...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathies
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblasts

Share to Fibrosis

Share to Isoproterenol

Share to Latent TGF-beta Binding Proteins

Share to Mice, Inbred C3H

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 29950403
DOI: 10.1161/CIRCULATIONAHA.118.035420
PMCID: PMC6202226

Genes

LTBP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Regulation of Fibroblast Activation and Proliferation in Cardiac Fibrosis.PMID 29950403Read ↗

Integration mapping of cardiac fibroblast single-cell transcriptomes elucidates cellular principles of fibrosis in diverse pathologiesSemantic proximity Read ↗

The Role of Cardiac Fibroblast Heterogeneity in Myocardial Fibrosis and Its Novel Therapeutic PotentialSemantic proximity Read ↗

The Genetic Architecture of Carbon Tetrachloride-Induced Liver Fibrosis in Mice.Semantic proximity Read ↗

Cardiac Fibroblast DiversitySemantic proximity Read ↗

Gene expression analysis to identify mechanisms underlying heart failure susceptibility in mice and humans.Semantic proximity Read ↗

Cardiac fibroblast diversity in health and diseaseSemantic proximity Read ↗

Defining Transcriptomic Heterogeneity between Left and Right Ventricle-Derived Cardiac FibroblastsSemantic proximity Read ↗

Diverse origins and activation of fibroblasts in cardiac fibrosisSemantic proximity Read ↗

A Tale of Two Mice: genetics of model mouse strains suggest a transcriptional basis for risk and resistance in idiopathic pulmonary fibrosisSemantic proximity Read ↗

Fibroblast Plasticity in Pulmonary and Cardiovascular Fibrosis: Mechanistic Insights and Emerging Therapeutic TargetsSemantic proximity Read ↗

Cardiac fibroblast sub-types in vitro reflect pathological cardiac remodeling in vivoSemantic proximity Read ↗

Single–cell transcriptional and epigenetic mapping reveals cellular and molecular mechanisms driving non-ischemic cardiac fibrosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.