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Article

The Multidrug Transporter MdfA Deviates from the Canonical Model of Alternating Access of MFS Transporters.

Journal of molecular biology - 18 Sept 2020

Yardeni Eliane H, Mishra Smriti, Stein Richard A, Bibi Eitan, Mchaourab Hassane S

Abstract excerpt

The prototypic multidrug (Mdr) transporter MdfA from Escherichia coli efflux chemically- dissimilar substrates in exchange for protons. Similar to other transporters, MdfA purportedly functions by alternating access of a central substrate binding pocket to either side of the membrane. Accordingly, MdfA should open at the cytoplasmic side and/or laterally toward the membrane to enable access of drugs into its...

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Identifiers

PMID: 32860775
DOI: 10.1016/j.jmb.2020.08.017
PMCID: PMC7541688

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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