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Substrate Specificity Checkpoints of the Multidrug Efflux Pump MexF from Pseudomonas aeruginosa.

ACS infectious diseases - 13 Feb 2026

Uddin Muhammad R, Gervasoni Silvia, Malloci Giuliano, Ruggerone Paolo, Zgurskaya Helen I

Abstract excerpt

Multidrug efflux pumps of the resistance-nodulation-division (RND) superfamily are major contributors to antibiotic resistance in Pseudomonas aeruginosa. Among these, the MexEF-OprN system, when overproduced in clinical isolates, confers resistance to fluoroquinolones, trimethoprim, and chloramphenicol. The inner-membrane RND transporter MexF in this complex exhibits a relatively narrow substrate specificity and...

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Anti-Bacterial Agents
Bacterial Outer Membrane Proteins
Binding Sites
Drug Resistance, Multiple, Bacterial
Membrane Transport Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microbial Sensitivity Tests

Pseudomonas aeruginosa

Substrate Specificity

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PMID: 41543281
DOI: 10.1021/acsinfecdis.5c00760
PMCID: PMC12910583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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