Article
The Lipid Bilayer Modulates the Structure and Function of an ATP-binding Cassette Exporter.
The Journal of biological chemistry - 26 Feb 2016
Zoghbi Maria E, Cooper Rebecca S, Altenberg Guillermo A
Abstract excerpt
ATP-binding cassette exporters use the energy of ATP hydrolysis to transport substrates across membranes by switching between inward- and outward-facing conformations. Essentially all structural studies of these proteins have been performed with the proteins in detergent micelles, locked in specific conformations and/or at low temperature. Here, we used luminescence resonance energy transfer spectroscopy to study...
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